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Home Skin Health Perioral Dermatitis: Description, Causes, And Treatment Protocol

Perioral Dermatitis: Description, Causes, And Treatment Protocol

by Iris Lee
Perioral Dermatitis.


Perioral Dermatitis is a persistent, inflamed skin disorder that causes a rash around the eyes, nose, and mouth. Although it can be experienced by males and children, this disorder mostly impacts women within the age range of 20 to 45 years old. Perioral Dermatitis’ difficult treatment is due to its precise cause remaining unknown. However, various factors, including topical irritants, hormone imbalances, and microbiological factors, have a role in its development.

Generally appearing on the skin around the eyes, nose, and mouth, Perioral Dermatitis manifests as a pink or red rash with tiny bumps and pustules. The skin that is affected can appear dry, itchy, flaky, and occasionally put forth a burning sensation. A proper diagnosis is crucial for the right kind of treatment because the condition frequently resembles acne or rosacea.

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Perioral Dermatitis: Description, Causes, And Treatment Protocol is an original (HealthXWire) article.

Possible Causes

The precise reason for Perioral Dermatitis remains a mystery to specialists. However, many probable causes and contributory elements are relevant to its presence. These elements probably work together to make susceptible people develop Perioral dermatitis. The following are some of the potential reasons for Perioral Dermatitis:

Steroid Ointments or Creams: People who misuse topical corticosteroids improperly or for an extended period of time might contribute to the cause of Perioral Dermatitis. When usage stops, these drugs can have rebound inflammation due to withdrawal symptoms and skin thinning, particularly with high or powerful formulations. Such rebound impact has the potential to cause or exacerbate Perioral Dermatitis.

Topical Irritants: Using specific skincare, cosmetic, or topical drugs can result in Perioral Dermatitis. The chemicals found in those cosmetics, which include scents, preservatives, dyes, and even some sunscreen agents, may irritate one’s skin and upset its natural balance, causing inflammation and the onset of the skin disorder.

Hormonal Factors: Especially in women, hormonal abnormalities or variations contribute to the onset of Perioral Dermatitis. Such variations frequently happen during pregnancy, menstruation, or when taking oral contraceptives. Differences in hormone levels may impact the skin’s immune system and barrier function, rendering it more prone to inflammation along with the emergence of Perioral Dermatitis.

Fluoridated Toothpaste: Perioral Dermatitis is frequently linked by relevant specialists to the onset or worsening of toothpaste that contains fluoride. Fluoride may modify the usual microbiota on the skin and damage the skin barrier, increasing a person’s vulnerability to the illness.

Microbial Factors: Perioral Dermatitis can be exacerbated by specific fungi and bacteria. In some situations, bacterial species like Streptococcus species and Staphylococcus aureus, in addition to yeast species like Candida, might be involved. These microorganisms can upset the skin’s natural equilibrium and cause an inflammatory reaction.

Environmental Factors: Perioral Dermatitis can occur or worsen due to environmental factors including pollution or exposure to unfavorable weather conditions like cold, dry wind. These elements may result in irritation, dryness, and inflammation of the skin.

Genetic Predisposition: Perioral Dermatitis frequently runs in families, suggesting that there might be a genetic susceptibility to it. Nevertheless, particular genes or genetic components linked to the illness continue to be researched.

Exacerbating and Mitigating Factors

The following are examples of Perioral Dermatitis’ aggravating factors:

Steroid Ointments or Creams: Topical corticosteroids, particularly effective or extremely potent formulations, may trigger rebound effects and make Perioral Dermatitis worsen when used excessively or improperly. These lotions may at first offer short-term comfort, but eventually, they may cause skin thinning and a higher vulnerability to infections.

Emotional Stress: According to reports, Perioral Dermatitis and other skin problems can worsen because of stress and mental factors. Stress may cause or exacerbate symptoms by impairing the immune system’s functions and upsetting the body’s natural equilibrium.

Harsh Weather Conditions: Extreme weather exposure, like exposure to cold, arid conditions, or high temperatures, can cause or aggravate Perioral Dermatitis. These ailments can dry up the skin and interfere with its normal function as a barrier, causing inflammation to worsen.

The mitigating factors of Perioral Dermatitis are as follows:

Gentle Skincare Routine: Developing a mild skincare routine is essential for controlling Perioral Dermatitis. You should apply gentle, fragrance-free cleansers instead of strong exfoliants that might aggravate the skin further. Your skin must then be gently patted dry without rubbing.

Minimal Usage of Cosmetic Items: Reduce your usage of cosmetics, especially those with substances that could irritate your skin or cause acne. Choose items that are less prone to clog pores and exacerbate the condition—non-comedogenic, fragrance-free ones.

Sun Protection: Since UV rays can cause or exacerbate symptoms, it’s crucial for those affected to shield the affected region from prolonged sun exposure. High SPF broad-spectrum sunscreens must be used, in addition to protective clothing alongside shade throughout peak sunlight hours.

Stress Management: Using stress-reduction strategies, such as frequent exercise, meditation, or hobby-related activities, might help lower emotional stress and perhaps even alleviate symptoms. Techniques for reducing stress may also benefit the overall health of the skin.

Healthy Lifestyle: Overall skin health may be improved by leading a healthy lifestyle that includes a balanced diet, frequent exercise, and enough sleep. An adequately fueled body is better able to control inflammation and aid in the course of recovery.

Emotional Stress.

Standard Treatment Protocol

The conventional course of action for Perioral Dermatitis entails a combination of the following oral and topical medicines:

Topical Medications:

  • Metronidazole

It is a topical antibiotic having the potential to suppress bacterial growth and minimize irritation. It can be administered twice daily and comes in cream or gel forms.

  • Erythromycin

It is another topical antibiotic with anti-inflammatory effects. Typically, it is utilized twice daily.

  • Azelaic Acid

This drug has antibacterial qualities and aids in restoring normal skin cell turnover. It might be used once or twice each day.

Oral Medications:

  • Oral Antibiotics

Oral antibiotics might be recommended in instances of resistant or acute Perioral Dermatitis. Minocycline, doxycycline, or tetracycline are examples of frequently employed antibiotics. These drugs aid in reducing inflammation and preventing bacterial overgrowth. Usually, a course of treatment lasts from some weeks to several months.

  • Oral Immunosuppressants

To assist modify your body’s immune system and lessen inflammation, low-dose isotretinoin or tetracycline can be administered in some circumstances.

Avoiding Trigger Factors: Treatment for this disorder must include locating and removing triggers. Fluoridated toothpaste, thick moisturizers, topical corticosteroids, and cosmetics containing certain ingredients are some examples of prevalent triggers. Patients are urged to stop using such products and switch to a mild skincare regimen.

Moisturizer for healthy skin.

Treatment Options

Over-the-Counter Formulations:

  • Gentle Cleansers

To reduce inflammation, one must apply gentle, fragrance-free cleansers.

  • Moisturizers

To moisturize the skin without clogged pores, one should apply fragrance-free, non-comedogenic moisturizers.

  • Barrier Creams

A light coating of a soft barrier cream, like petroleum jelly or zinc oxide, may shield the skin and promote wound healing.

Nutritional Supplements: Although there is little information about Perioral Dermatitis, some dietary supplements may promote overall skin condition and decrease inflammation. Several supplements are frequently advised:

  • Omega-3 Fatty Acids

Omega-3 fatty acids are included in flaxseed and fish oils and possess anti-inflammatory qualities that may benefit skin health.

  • Zinc

Zinc has been linked to better skin conditions and is important in controlling immunological responses.

  • Vitamin A and vitamin D

These vitamins are essential for maintaining healthy skin and may aid in the recovery procedure.

Natural Remedies: Despite the paucity of data, certain herbal treatments have been proposed as supplementary treatments for Perioral Dermatitis. These consist of:

  • Aloe Vera Gel

Natural aloe vera gel, which is well-known for its calming effects, can be applied to the affected region to help lessen swelling and itching.

  • Calendula or Chamomile Extracts

These extracts may be administered topically and possess anti-inflammatory qualities to reduce symptoms.

  • Honey

Using raw honey on the affected region can potentially provide relief due to its antibacterial and wound-healing characteristics.

Herbal Remedies: Certain herbal treatments have antibacterial or anti-inflammatory characteristics and can help with Perioral Dermatitis management. Nevertheless, you should be cautious as they could irritate certain people’s skin. Some instances are:

  • Neem Oil

Neem oil, which comes from neem trees, is antifungal, antibacterial, and anti-inflammatory, which renders it possibly useful in treating Perioral Dermatitis.

  • Tea Tree Oil

Tea tree oil is well known for its antibacterial qualities and may be administered topically to fight fungal or bacterial infestations.

Before implementing any adjunct treatments or natural remedies, it is imperative for you to seek medical advice from a qualified individual, preferably a dermatologist. Depending on the condition’s severity and the client’s specific requirements, they can offer tailored recommendations. The general control of Perioral Dermatitis may be further aided by maintaining appropriate skincare routines, avoiding recognized irritants, and living a healthy way of life.

Vitamin D supplements.


Perioral Dermatitis is a skin disorder that presents obstacles for those who are affected.  A well-rounded treatment protocol is/was recommended in/by this article.  It is not enough to treat the symptoms because the entire person must be treated, as this disorder can be affected by things like stress and emotions as well as hormones and genetics. Women are most susceptible to this disorder, although other people who are not adult women have been known to suffer from it as well. Medicines as well as lifestyle changes may be what is necessary to treat and fully recover from Perioral Dermatitis. 

DNA structure.
Additional resources for further reference:
  1. “What is perioral dermatitis and who can it be treated?” Retrieved from:
  3. “Perioral Dermatitis.” Retrieved from:
  4. “Perioral Dermatitis.” Retrieved from:

Important Note: The information contained in this article is for general informational purposes only, and should not be construed as health or medical advice, nor is it intended to diagnose, prevent, treat, or cure any disease or health condition. Before embarking on any diet, fitness regimen, or program of nutritional supplementation, it is advisable to consult your healthcare professional in order to determine its safety and probable efficacy in terms of your individual state of health.

Regarding Nutritional Supplements Or Other Non-Prescription Health Products: If any nutritional supplements or other non-prescription health products are mentioned in the foregoing article, any claims or statements made about them have not been evaluated by the U.S. Food and Drug Administration, and such nutritional supplements or other health products are not intended to diagnose, treat, cure, or prevent any disease.

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